In very small amounts, alcohol can help a person feel more relaxed or less anxious. More alcohol causes greater changes in the brain, resulting in intoxication . People who have overused alcohol may stagger, lose their coordination, and slur their speech. They will probably be confused and disoriented. Depending on the person, intoxication can make someone very friendly and talkative or very aggressive and angry. Reaction times are slowed dramatically — which is why people are told not to drink and drive. People who are intoxicated may think they're moving properly when they're not. They may act totally out of character.
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At low or moderate doses, alcohol acts primarily as a positive allosteric modulator of GABA A . Alcohol binds to several different subtypes of GABA A , but not to others. The main subtypes responsible for the subjective effects of alcohol are the α 1 β 3 γ 2 , α 5 β 3 γ 2 , α 4 β 3 δ and α 6 β 3 δ subtypes, although other subtypes such as α 2 β 3 γ 2 and α 3 β 3 γ 2 are also affected. Activation of these receptors causes most of the effects of alcohol such as relaxation and relief from anxiety, sedation, ataxia and increase in appetite and lowering of inhibitions that can cause a tendency toward violence in some people.